Search Results - edmond+lavoie

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Fluorescent Probe for Bacterial Cell Imaging and Screening of New Antibacterial Drugs Visualization of the impact of FtsZ-targeting drug treatment in both Gram-positive and Gram-negative bacterial strains using BOFP. Bacteria were labeled with BOFP for 5 minutes just prior to visualization. Differential interference contrast (DIC) shows unstained bacteria and fluorescence shows BOFP-labeled bacteria.Invention Summary:At least 2.8 million... Published: 12/8/2021   |   Inventor(s): Daniel Pilch, Edgar Ferrer-Gonzalez, Edmond LaVoie Keywords(s): Drug Discovery/Screening Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Infectious Disease, Technology Classifications > Research Tools

Prodrugs and ADC Derivatives of Non-Camptothecin TOP1-Targeting Cancer Chemotherapeutics Schematic Structure of an Antibody-Drug Conjugate (ADC) (en.wikipedia.org)Invention Summary:Topoisomerase 1 (Top1) is an essential enzyme in mammalian cells and is a validated target for the treatment of human cancers. Topotecan and irinotecan (camptothecin analogues) are two FDA approved Top1-targeted drugs. Despite being powerful anticancer drugs,... Published: 12/8/2021   |   Inventor(s): Edmond LaVoie, Ajit Parhi Keywords(s): Anti-cancer, Small molecules Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics