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SAHMI: Microbiome-based screening method for cancer and other diseases
Screening methodology and principle data identifying differences in
microbiome diversity from disease state in pancreatic cancer
Invention Summary:
The microbiome plays an essential role in the prognosis and progression of disease and health, as seen in cancers like pancreatic cancer. Pancreatic cancer is rising in majority of cancer...
Published: 7/28/2022
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Inventor(s): Subhajyoti De, Bassel Ghaddar
Keywords(s): Anti-cancer, Bioinformatics, Biomarkers, Cancer biomarkers
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics, Technology Classifications > Cancer
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Biomarkers for Identifying Patients at High Risk of Progressing
from Barrett’s Esophagus to Esophageal Adenocarcinoma
Invention Summary:
Esophageal adenocarcinoma (EAC) has a poor prognosis with a 5-year overall survival of 15-20%. In the past 3 decades, the incidence of EAC increased 600-800%. Barrett’s esophagus (BE), the precancerous lesion for EAC, has approximately 0.11 to 1.6% annual rate of progression to EAC. Currently, the guidelines for BE surveillance...
Published: 12/8/2021
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Inventor(s): Zhongren ("David") Zhou
Keywords(s): Anti-cancer, Biomarkers, Cancer biomarkers
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics, Technology Classifications > Cancer
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A Method to Predict the Response of Individual Patient to Cocktails of Radiopharmaceuticals, Chemotherapeutics or Other Agents
Representative pictures showing wide variation in cellular uptake of radiopharmaceuticals.
Invention Summary:
A number of therapeutic cocktails have been developed to treat various diseases including metastatic cancers. However, patients vary widely in their beneficial responses to such therapies. It has been found that the uptake of targeted therapeutic...
Published: 12/8/2021
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Inventor(s): Roger Howell, Behrooz Vaziri, Han Wu, Atam Dhawan
Keywords(s): Antibodies, Anti-cancer
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Cancer, Technology Classifications > Software & Algorithms, Technology Classifications > Software & Copyright
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Method to Predict the Response of Individual Patient to Cocktails of Radiopharmaceuticals, Chemotherapeutics, or Other Agents
Representative pictures showing wide variation in cellular uptake of radiopharmaceuticals.
Invention Summary:
A number of therapeutic cocktails have been developed to treat various diseases including metastatic cancers. However, patients vary widely in their beneficial responses to such therapies. It has been found that the uptake of targeted therapeutic...
Published: 12/8/2021
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Inventor(s): Roger Howell, Jordan Pasternack, John Akudugu
Keywords(s): Antibodies, Anti-cancer
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Cancer
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Method for Generating Memory T-cells In Vitro and Their Use in Immunotherapy
Invention Summary:
Dendritic cell-based immunotherapies have been tested for the treatment of cancer patients with limited success. The limited success is probably due to the ineffective activation of specific T-cells by injected dendritic cells. In vitro generation of memory T-cells that can respond to cancer cells could circumvent ineffective...
Published: 12/8/2021
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Inventor(s): Shigeko Yamashiro, Fumio Matsumura, Aya Matsumura
Keywords(s): Anti-cancer, Immunoassay
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Research Tools, Technology Classifications > Therapeutics
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CAR-T and CAR-NK Immunotherapy for Hepatocellular Carcinoma
CAR-NK cells control progression of HCC in PDX modelInvention Summary:Chimeric antigen receptor (CAR)-modified T cell therapy has become a promising immune-therapeutic strategy for the treatment of various blood cancers. Hepatocellular carcinoma (HCC) is the most common type of cancer that starts in the liver. HCC is the third most common cause of cancer-related...
Published: 12/8/2021
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Inventor(s): Dongfang Liu, Mustafa Mozael
Keywords(s): Anti-cancer, Bioengineering scaffolds
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Cancer
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A Novel Approach for Expansion of NK and CAR-modified NK Cells
Fold expansion of NK cells from cord blood expanded with irradiated K562-mIL21 and RU-Feeder CellsInvention Summary:Chimeric antigen receptor T-cell immunotherapy (CAR-T cell therapy) requires engineering of T cells harvested from the patient. Natural killer (NK) cells are also cytotoxic immune cells, but work somewhat differently from T cell. Engineered...
Published: 12/8/2021
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Inventor(s): Dongfang Liu
Keywords(s): Anti-cancer, Cell Lines
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Cancer, Technology Classifications > Cell Therapy
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Leukemia Inhibitor Factor as a Radioprotectant for Gastrointestinal Injury Following Cancer Radiotherapy
LIF protects mice from Ionizing radiation:
survival is measured in control group without treatment (WT) vs. those treated with LIF (WT + LIF).
Invention Summary:
Currently there is no effective therapy for prevention or treatment of radiation therapy-induced gastrointestinal (GI) tract injury.
Rutgers researchers have recently discovered that...
Published: 12/8/2021
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Inventor(s): Wenwei Hu, Zhaohui Feng, Jianming Wang, Huaying Wang
Keywords(s): Anti-cancer, Gastrointestinal disease, Peptides
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Cancer, Technology Classifications > Therapeutics
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New Biomarker to Guide Cancer Immunotherapy
RNA expression of ERV3-2 (for 2 different primers) is significantly higher in tumors from responders compared with tumors from non-responders.Invention Summary:Immunotherapy has led to dramatic responses in many cancer types, but only a minority of patients has clinical benefit. In certain cancers, including renal cell carcinoma, no clear correlation...
Published: 12/8/2021
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Inventor(s): Shridar Ganesan, Gyan Bhanot, Anshuman Panda, W. Kimryn Rathmell, Aguirre de Cubas
Keywords(s): Anti-cancer, Biomarkers, Cancer biomarkers
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics, Technology Classifications > Therapeutics
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Novel Zinc Metallochaperone (ZMC) Complexes for Treatment of p53-Mutated Cancers
A) Novel mechanism of action: a short exposure to ZMCs increases zinc levels in tumors enough to restore normal structure/function to mutant p53 which leads to p53 mediated cancer cell death. B) Novel formulation: Synthesizing ZMCs as a zinc-loaded complex (Zn-1) improves survival in a pancreatic cancer mouse model compared to the ZMC compound alone....
Published: 12/8/2021
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Inventor(s): Spencer Kimball, Darren Carpizo, John Gilleran
Keywords(s): Anti-cancer, Small molecules
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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