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SAHMI: Microbiome-based screening method for cancer and other diseases
Screening methodology and principle data identifying differences in
microbiome diversity from disease state in pancreatic cancer
Invention Summary:
The microbiome plays an essential role in the prognosis and progression of disease and health, as seen in cancers like pancreatic cancer. Pancreatic cancer is rising in majority of cancer...
Published: 7/28/2022
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Inventor(s): Subhajyoti De, Bassel Ghaddar
Keywords(s): Anti-cancer, Bioinformatics, Biomarkers, Cancer biomarkers
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics, Technology Classifications > Cancer
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Biomarkers for Identifying Patients at High Risk of Progressing
from Barrett’s Esophagus to Esophageal Adenocarcinoma
Invention Summary:
Esophageal adenocarcinoma (EAC) has a poor prognosis with a 5-year overall survival of 15-20%. In the past 3 decades, the incidence of EAC increased 600-800%. Barrett’s esophagus (BE), the precancerous lesion for EAC, has approximately 0.11 to 1.6% annual rate of progression to EAC. Currently, the guidelines for BE surveillance...
Published: 12/8/2021
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Inventor(s): Zhongren ("David") Zhou
Keywords(s): Anti-cancer, Biomarkers, Cancer biomarkers
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics, Technology Classifications > Cancer
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An Algorithm for Identification of Treatment-response Biomarkers to Chemotherapies
Invention Summary:In the last decade, several computational methods have been successfully applied to understand cancer initiation and progression through integration of genomic and epigenomic data. However, despite recent advances in discovering a wide array of novel chemotherapy agents, identification of patients with poor and favorable response prior...
Published: 12/8/2021
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Inventor(s): Antonina Mitrofanova, Nusrat Epsi
Keywords(s): Bioinformatics, Biomarkers, Cancer biomarkers, Data Science, Digital Health
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics, Technology Classifications > Software & Algorithms, Technology Classifications > Software & Copyright
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New Biomarker to Guide Cancer Immunotherapy
RNA expression of ERV3-2 (for 2 different primers) is significantly higher in tumors from responders compared with tumors from non-responders.Invention Summary:Immunotherapy has led to dramatic responses in many cancer types, but only a minority of patients has clinical benefit. In certain cancers, including renal cell carcinoma, no clear correlation...
Published: 12/8/2021
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Inventor(s): Shridar Ganesan, Gyan Bhanot, Anshuman Panda, W. Kimryn Rathmell, Aguirre de Cubas
Keywords(s): Anti-cancer, Biomarkers, Cancer biomarkers
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics, Technology Classifications > Therapeutics
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Panel & Software to Predict Therapeutic Resistance in Cancer Treatment
Invention Summary:According to the American Cancer Society, prostate cancer is the second most common malignancy in men and the second-highest cancer-related cause of death in American men. Androgen deprivation therapy (ADT), which reduces or prevents male hormones (androgens) from interacting with cancer cells, has been shown to be beneficial in treating...
Published: 12/8/2021
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Inventor(s): Antonina Mitrofanova, Sukanya Panja
Keywords(s): Bioinformatics, Biomarkers, Cancer biomarkers, Prostate Cancer
Category(s): Technology Classifications > Software & Copyright, Technology Classifications > Software & Algorithms, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics
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DNA Nanodevices for Point-of-Care Testing
DNA nanodevice can detect 0.1 nm microRNAInvention Summary: Point-of-Care (POC) testing is defined as a simple operated, easy-to-read, rapid and low-cost medical diagnosis that can be used by non-specialists at home, in the field or on an ambulance. It provides timely diagnostic results, enabling early diagnosis of diseases, protective therapy and rapid...
Published: 12/8/2021
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Inventor(s): Jinglin Fu, Sung Won Oh, Adriana Pereira
Keywords(s): Bioengineering scaffolds, Biomarkers, Cancer biomarkers
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics, Technology Classifications > COVID-19, Technology Classifications > Research Tools, Technology Classifications > Infectious Disease
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Rapid Molecular Assays for Fungal Infections
Sensitivity of real-time NASBA assay for fungi. B: pan-Candida probe, C: pan-Aspergillus probeInvention Summary: Fungal infections are as significant cause of mortality and morbidity when not rapidly diagnosed and treated. However, the current standard of care for diagnosis is blood culture, a method limited by the time to diagnosis (1-2 days), frequency...
Published: 12/8/2021
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Inventor(s): David Perlin, Steven Park, David Denning
Keywords(s): Biomarkers
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics
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Detection of Human Endogenous Retrovirus Expression in Cancer and Normal Cells
Invention Summary:Approximately 8% of the human genome consists of sequences classified as Human endogenous retroviruses (HERVs), which are remnants of ancient retroviral integrations in the human genome. While HERV elements have degenerated over millions of years of evolution and most of them can no longer encode complete proteins, some HERV genes...
Published: 12/8/2021
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Inventor(s): Vincent Tsiagbe, Yu Li
Keywords(s): Anti-cancer, Biomarkers, Cancer biomarkers
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Research Tools, Technology Classifications > Diagnostics, Technology Classifications > Cancer
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