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“Off-the-shelf” CAR-NK cells for SARS-CoV-2 targeting in COVID-19 treatment
S309-CAR cells show higher lysis of cells transfected with the RBD of the SARS-CoV-2 spike protein compared to control.
Invention Summary:
COVID-19 remains a pandemic and a critical medical concern across the world. Patients with severe symptoms who are admitted into the ER have grim prognosis and are sometimes faced with expensive and limited...
Published: 12/8/2021
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Inventor(s): Dongfang Liu, Minh Ma, Saiaditya Badeti
Keywords(s): Antiviral, Bioengineering scaffolds
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > COVID-19
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“Off-the-shelf” CAR-NK cells for enhanced SARS-CoV-2 targeting in COVID-19 treatment
CR3022-CAR cells have greater lysis of cells transfected with the RBD of the SARS-CoV-2 spike protein compared to control.
Invention Summary:
COVID-19 remains a pandemic and a critical medical concern across the world. Patients with severe symptoms are admitted into the ER have grim prognosis and have expensive limited treatment options. A large...
Published: 12/8/2021
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Inventor(s): Dongfang Liu, Minh Ma, Saiaditya Badeti
Keywords(s): Antiviral, Bioengineering scaffolds
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > COVID-19, Technology Classifications > Therapeutics, Technology Classifications > Cell Therapy
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Rapid Cell Assembly for 3D Culture
A. Schematic diagram showing the self-assembly of a spheroid.
B. Schematic showing transplantation of spheroids for the repair/regeneration of spinal cord
Invention Summary:
3D cell culture including organoid and spheroid cultures is at the center stage of biomedical research. It is widely applied in organ development research, disease modeling,...
Published: 12/8/2021
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Inventor(s): Ki-Bum Lee
Keywords(s): Bioengineering scaffolds, Tissue Engineering
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Research Tools
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CAR-T and CAR-NK Immunotherapy for Hepatocellular Carcinoma
CAR-NK cells control progression of HCC in PDX modelInvention Summary:Chimeric antigen receptor (CAR)-modified T cell therapy has become a promising immune-therapeutic strategy for the treatment of various blood cancers. Hepatocellular carcinoma (HCC) is the most common type of cancer that starts in the liver. HCC is the third most common cause of cancer-related...
Published: 12/8/2021
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Inventor(s): Dongfang Liu, Mustafa Mozael
Keywords(s): Anti-cancer, Bioengineering scaffolds
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Cancer
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Scaffold-Free Biological Assemblies for Tissue Modeling and Regeneration
Invention Summary:The evolution of in vitro-engineered scaffold-free tissues for tissue modeling and regenerative medicine has been driven by the need to recapitulate the cellular organization of endogenous tissues and to avoid undesired scaffold-related side effects upon implantation. Methods to produce scaffold-free tissue or cell assemblies have...
Published: 12/8/2021
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Inventor(s): Ki-Bum Lee, Letao Yang
Keywords(s): Bioengineering scaffolds, Tissue Engineering, Wound healing
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Cell Therapy, Technology Classifications > Therapeutics
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DNA Nanodevices for Point-of-Care Testing
DNA nanodevice can detect 0.1 nm microRNAInvention Summary: Point-of-Care (POC) testing is defined as a simple operated, easy-to-read, rapid and low-cost medical diagnosis that can be used by non-specialists at home, in the field or on an ambulance. It provides timely diagnostic results, enabling early diagnosis of diseases, protective therapy and rapid...
Published: 12/8/2021
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Inventor(s): Jinglin Fu, Sung Won Oh, Adriana Pereira
Keywords(s): Bioengineering scaffolds, Biomarkers, Cancer biomarkers
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics, Technology Classifications > COVID-19, Technology Classifications > Research Tools, Technology Classifications > Infectious Disease
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Biodegradable Scaffold for Advanced Stem Cell Therapy
Schematic diagram representing the self assembly of Laminin (ECM) and the MnO2 sheet
Invention Summary:
While regenerative stem cell therapy has been a promising approach for transplant medicine and surgery, there have been challenges due to low transplantation survival rate and poor selectivity in differentiation.
Researchers at Rutgers University...
Published: 7/28/2022
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Inventor(s): Ki-Bum Lee, Letao Yang
Keywords(s): Bioengineering scaffolds, Biomaterials, Tissue Engineering
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Biomaterials, Technology Classifications > Therapeutics
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Biomimetic, Bioactive Dental Implants
Left: 3D printed mold; Center: prototype bioactive implant; Right: prototype lateral incisor implant restored with acrylic temporary crown (after implantation).Invention Summary: While titanium dental implants are the current state of the art for tooth replacement, they involve an invasive surgical procedure and significant risks. Aside from intraoperative...
Published: 12/8/2021
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Inventor(s): Amir Fakhrzadeh
Keywords(s): Bioengineering scaffolds, Biomaterials, Implants, Polymers & Composites
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Biomaterials, Technology Classifications > Medical Devices, Technology Classifications > Dental, Technology Classifications > Polymers/Composites/Materials
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Type-I Collagen Methacrylamide-Derivatized Hydrogels
Invention Summary:Natural material collagen has the benefits of bioactivity, biodegradability, and innate adhesiveness and self-assemble, which allows the material to be injected into a defect of almost any geometry with minimal invasion, and then automatically become a solid to provide a stable matrix but have the limited control of mechanical properties....
Published: 12/8/2021
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Inventor(s): David Shreiber, Ian Gaudet
Keywords(s): Bioengineering scaffolds, Wound healing
Category(s): Technology Classifications > Biomaterials, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences
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Three-Dimensional Pre-Vascularized Scaffold
Schematic of load-bearing scaffold: osteonal cortical section, porous trabecular section, vascularized osteon, hydroxyapatite columnsInvention Summary:This load-bearing scaffold mimics the native structure of cortical and trabecular bone to improve outcomes of orthopaedic surgeries. The biodegradable, polymeric scaffold has a porous trabecular section...
Published: 12/8/2021
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Inventor(s): Joseph Freeman, Brittany Taylor, Tea Arapovic, Pushpendra Pankaj PATEL
Keywords(s): Bioengineering scaffolds
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Biomaterials, Technology Classifications > Medical Devices
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