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“Off-the-shelf” CAR-NK cells for SARS-CoV-2 targeting in COVID-19 treatment
S309-CAR cells show higher lysis of cells transfected with the RBD of the SARS-CoV-2 spike protein compared to control.
Invention Summary:
COVID-19 remains a pandemic and a critical medical concern across the world. Patients with severe symptoms who are admitted into the ER have grim prognosis and are sometimes faced with expensive and limited...
Published: 12/8/2021
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Inventor(s): Dongfang Liu, Minh Ma, Saiaditya Badeti
Keywords(s): Antiviral, Bioengineering scaffolds
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > COVID-19
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“Off-the-shelf” CAR-NK cells for enhanced SARS-CoV-2 targeting in COVID-19 treatment
CR3022-CAR cells have greater lysis of cells transfected with the RBD of the SARS-CoV-2 spike protein compared to control.
Invention Summary:
COVID-19 remains a pandemic and a critical medical concern across the world. Patients with severe symptoms are admitted into the ER have grim prognosis and have expensive limited treatment options. A large...
Published: 12/8/2021
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Inventor(s): Dongfang Liu, Minh Ma, Saiaditya Badeti
Keywords(s): Antiviral, Bioengineering scaffolds
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > COVID-19, Technology Classifications > Therapeutics, Technology Classifications > Cell Therapy
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A NOVEL METHOD OF GENERATING LIVE-ATTENUATED REPLICATION-DEFECTIVE DNA VIRUSES FOR VACCINE DEVELOPMENT
Method for Generating Replication-Defective DNA Virus for Safer Live-Attenuated VaccinesPrimary Inventor: Hua Zhu, Ph.D.Department of Microbiology, Biochemistry, and Molecular Genetics RU Tech ID #: 2021-002 Invention Summary: Live-attenuated vaccines are widely used for immunization against many viral diseases. However, there are still...
Published: 12/8/2021
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Inventor(s): Hua Zhu, Dabbu Jaijyan, Moses Lee
Keywords(s): Antiviral
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Vaccine
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Sigma-1 Receptor Antagonists – Non-Addictive Pain Management
Invention Summary:
The sigma 1 receptor (S1R), a molecular chaperone protein located in the endoplasmic reticulum and plasma membranes, plays important roles in various pathological disorders including pain. The potential commercial applications of novel S1R antagonists are twofold: 1) as stand-alone therapy for the treatment of chronic neuropathic...
Published: 12/8/2021
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Inventor(s): William Welsh, Youyi Peng
Keywords(s): Antiviral, Neurological disorder & neuropathic pain, Small molecules
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Novel Phosphatidylserine-Targeting Immunobiologicals for Cancer and Viral Treatment
PS-targeting biological inhibits tumor growth and virus infection Invention Summary: Phosphatidylserine (PS) is a phospholipid that is restricted to the inner plasma membrane in healthy cells but is externalized in apoptotic or stressed cells abundantly present in tumor microenvironment or in sites of virus infection. PS is also present on the surface...
Published: 12/8/2021
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Inventor(s): Sergei Kotenko, Viralkumar Davra, Raymond Birge
Keywords(s): Anti-cancer, Antiviral
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Novel Fusion Polypeptides as Antiviral and Cancer Therapeutics
Antitumor and antiviral effects of the fusion IFN-β-IFN-λ in vivoInvention Summary:Type I and Type III interferons (IFNs) are well known for their potent broad-spectrum antiviral activities. In addition, these pluripotent cytokines can also regulate cell growth and differentiation, tissue homeostasis, angiogenesis, as well as immune and...
Published: 12/8/2021
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Inventor(s): Sergei Kotenko, Joan Durbin
Keywords(s): Anti-cancer, Antiviral
Category(s): Technology Classifications > Therapeutics, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > COVID-19
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Low-Cost, Flexible, Paper-Based Plasma Sanitizer
Low-Cost, Flexible, Paper-Based Plasma SanitizerInvention Summary: Healthcare-associated infections (HAIs) are a major challenge facing disease control organizations and healthcare providers worldwide. In 2011, there were 721,800 cases of HAIs reported in the US, with 75,000 patients ultimately dying from the infections. Because a leading cause of HAIs...
Published: 12/8/2021
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Inventor(s): Aaron Mazzeo, Jingjin Xie, Qiang Chen
Keywords(s): Antibacterial, Antiviral, Cleaning/Disinfecting Products, Electronics, Flexible electronics, Packaging, Wound healing
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > COVID-19, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Electronics/Semiconductor
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IFN-Lambda1 Polypeptides as Antiviral and Anticancer Therapeutics
Only IFN-λ and not IFN-α protects mice from lethal high-virulence influenza A virus infection
Invention Summary:
Interferons (IFNs) are well known for their potent broad-spectrum antiviral activities. In addition, these pluripotent cytokines can also regulate cell growth and differentiation, tissue homeostasis and angiogenesis, and immune...
Published: 12/8/2021
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Inventor(s): Sergei Kotenko, Grant Gallagher
Keywords(s): Antiviral
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Novel Monodisperse PEGtide Dendrons as Nanocarrier for Drug Delivery
Representative Structure of PEGtideInvention Summary: Dentrimers and dendrons have generated tremendous interest as nanocarriers for various drug delivery applications. Rutgers scientists have developed a series of novel monodisperse PEGtide dendrons with versatility to accommodate various drug delivery demands.PEGtide dendrons containing alternating...
Published: 12/8/2021
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Inventor(s): Patrick Sinko, Jieming Gao
Keywords(s): Antibacterial, Anti-cancer, Antiviral, Biomaterials
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Biomaterials, Technology Classifications > Therapeutics
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