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Novel Cationic Amphiphiles Control Biofilm Formation for Bacterial Vaginosis
Cationic amphiphiles greatly inhibits the biofilm formation of the pathogenic bacteria in BV.Cationic Amphiphile Concentration (μM)Invention Summary:Bacterial vaginosis (BV) is a common polymicrobial infection in women of reproductive age, affecting 10-30% of women in developed nations. BV can lead to serious complications such as abortion, premature...
Published: 12/8/2021
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Inventor(s): Kathryn Uhrich, Allison Faig
Keywords(s): Antibacterial, Biofilm, Biomaterials, Drug Delivery, Personal Care, Cosmeceuticals, Polymers & Composites
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Cationic Amphiphile for Antimicrobial Applications
The structure of CAms 5a, 5b, 5c, 8a, 8b, and 8c
Invention Summary:
The development of antibiotic-resistant bacteria is a prevalent concern that has prompted the development of new antimicrobial agents. Naturally-occurring antimicrobial peptides (AMPs) offer advantages over conventional antibiotics due to a reduced development of resistance...
Published: 12/8/2021
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Inventor(s): Kathryn Uhrich, Yingyue Zhang, Allison Faig, Michael (mikhail) Chikindas
Keywords(s): Antibacterial, Biomaterials, Peptides
Category(s): Technology Classifications > Therapeutics, Technology Classifications > Healthcare & Life Sciences
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Film Forming Foam (FFF) for Burn Wounds/Burnflex
Invention Summary:
Many of the available burn dressings on the market use latex, PVC or polyurethane as means of barrier-like components to protect the patient from outside elements. The current use of these components presents a problem of waste and contamination. Other available options in the market are hydrogel-based dressings that may...
Published: 12/8/2021
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Inventor(s): Maricely RamÃrez-Hernández, Tewodros Asefa, Jeffrey Boyd, Javiera Norambuena-Morales
Keywords(s): Antibacterial, Drug Delivery, Nanoparticles, Nanotechnology, Wound healing
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Nanotechnology, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Biomaterials, Technology Classifications > Consumer & Household Goods
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Pyrrole-based Inhibitors of PfPKG for the Treatment of Malaria
Invention Summary:
The emergence and spread of artemisinin-resistant plasmodium falciparum in Southeast Asia is a compelling reminder to develop new drugs for malaria prophylaxis and treatment. Drugs that target pre-erythrocytic stages are an essential component of the anti-malarial effort because a decrease in liver infection by sporozoites significantly...
Published: 12/8/2021
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Inventor(s): David Augeri, Purnima Bhanot, Raheel Fondekar, John Gilleran
Keywords(s): Antibacterial
Category(s): Technology Classifications > Healthcare & Life Sciences
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Novel Nanomaterial for Prolonged and Sustained Antibacterial Efficacy
a) BAC release profile at pH 4.0, 5.0, 6.5, and 7.4. b) The percentage of S. aureus survival upon exposure to BAC loaded nanoparticles after 0, 3, and 6 hours.Invention Summary: Quaternary ammonium cationic (QAC) surfactants are one of the preferred choices for antibacterial applications. The compounds are water and oil soluble, and they cover a broad...
Published: 12/8/2021
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Inventor(s): Tewodros Asefa, Viktor Dubovoy, Anjani Ganti, Jeffrey Boyd
Keywords(s): Antibacterial, Nanoparticles, Nanotechnology, Personal Care, Cosmeceuticals
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Nanotechnology, Technology Classifications > Healthcare & Life Sciences
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JSF-3285, A Novel KasA Inhibitor for Tuberculosis
Figure 1. Summary profile of JSF-3285: A) In vitro profile. B) X-ray crystal structure andbinding constant for complex with KasA. C) In vivo profile in mouse chronic infection model.Invention Summary:New antibacterial drugs that treat multidrug resistant mycobacterium tuberculosis (MDR TB) represent an area of high medical need. The current tuberculosis...
Published: 12/8/2021
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Inventor(s): Joel Freundlich, David Alland, Matthew Neiditch, Glenn Capodagli, Daigo Inoyama, Pradeep Kumar, Divya Awasthi
Keywords(s): Antibacterial
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Low-Cost, Flexible, Paper-Based Plasma Sanitizer
Low-Cost, Flexible, Paper-Based Plasma SanitizerInvention Summary: Healthcare-associated infections (HAIs) are a major challenge facing disease control organizations and healthcare providers worldwide. In 2011, there were 721,800 cases of HAIs reported in the US, with 75,000 patients ultimately dying from the infections. Because a leading cause of HAIs...
Published: 12/8/2021
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Inventor(s): Aaron Mazzeo, Jingjin Xie, Qiang Chen
Keywords(s): Antibacterial, Antiviral, Cleaning/Disinfecting Products, Electronics, Flexible electronics, Packaging, Wound healing
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > COVID-19, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Electronics/Semiconductor
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Versatile Biodegradable, Bioactive-Based Polymers for Topical, Cosmetic and Personal Care Applications
A. Structure of salicylic acid-based polymer and its degradation products.
B. Polymer degradation rates with different linker molecules.
C. Free ferulic acid in aqueous solution is unstable and turns brown after 10 days (left). Ferulic acid-based polymers are stable and aesthetically more pleasing in solution under the same condition (right).
Invention...
Published: 12/8/2021
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Inventor(s): Kathryn Uhrich, Jonathan Faig, Kervin Smith
Keywords(s): Antibacterial, Biomaterials, Drug Delivery, Personal Care, Cosmeceuticals, Polymers & Composites
Category(s): Technology Classifications > Healthcare & Life Sciences
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Novel Monodisperse PEGtide Dendrons as Nanocarrier for Drug Delivery
Representative Structure of PEGtideInvention Summary: Dentrimers and dendrons have generated tremendous interest as nanocarriers for various drug delivery applications. Rutgers scientists have developed a series of novel monodisperse PEGtide dendrons with versatility to accommodate various drug delivery demands.PEGtide dendrons containing alternating...
Published: 12/8/2021
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Inventor(s): Patrick Sinko, Jieming Gao
Keywords(s): Antibacterial, Anti-cancer, Antiviral, Biomaterials
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Biomaterials, Technology Classifications > Therapeutics
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Biodegradable and Biocompatible Bioactive-based Polymers - Versatile Platform Technology
Invention Summary:The Uhrich group at Rutgers University has developed various biodegradable polymers that chemically incorporate bioactive molecules, such as nonsteroidal anti-inflammatory drugs (e.g., salicylic acid), antioxidants (e.g., ferulic acid) and antimicrobials (e.g., carvacrol). Bioactive molecules are incorporated into polymer backbones...
Published: 12/8/2021
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Inventor(s): Kathryn Uhrich, Jonathan Faig, Kervin Smith
Keywords(s): Antibacterial, Bioengineering scaffolds, Biomaterials, Drug Delivery, Polymers & Composites
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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