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Novel System for High-Yield Production of Proteins and Protein Domains
Invention Summary:The synthesis of recombinant proteins using prokaryotic expression systems has been instrumental in producing valuable reagents for biomedical research and commercial products. However, the majority of in vivo expression systems have inherent limitations in most applications – including low yields, poor quality of the expressed...
Published: 12/8/2021
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Inventor(s): Gaetano Montelione, Stephen Anderson, Yuanpeng Huang, Thomas Acton
Keywords(s): Drug Discovery/Screening, Manufacturing, Peptides
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Research Tools
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Cationic Amphiphile for Antimicrobial Applications
The structure of CAms 5a, 5b, 5c, 8a, 8b, and 8c
Invention Summary:
The development of antibiotic-resistant bacteria is a prevalent concern that has prompted the development of new antimicrobial agents. Naturally-occurring antimicrobial peptides (AMPs) offer advantages over conventional antibiotics due to a reduced development of resistance...
Published: 12/8/2021
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Inventor(s): Kathryn Uhrich, Yingyue Zhang, Allison Faig, Michael (mikhail) Chikindas
Keywords(s): Antibacterial, Biomaterials, Peptides
Category(s): Technology Classifications > Therapeutics, Technology Classifications > Healthcare & Life Sciences
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Modified Kisspeptin Receptor Agonist as Novel Treatment of Non-Fatty Liver Disorder and Non-Alcoholic Steatohepatitis
TAK-448 protected insulin resistant, obese mice against the development of hepatic steatosis: H& E showing fatty liver.Invention Summary:Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder worldwide that can progress to steatohepatitis (NASH), the leading reason for liver transplants. In the U.S., there are nearly...
Published: 12/8/2021
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Inventor(s): M. Moshmi Bhattacharya Babwah, Andy Babwah, Sally Radovick, Fredrick Wondisford
Keywords(s): Diabetes & Metabolic Disorders, Peptides
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Leukemia Inhibitor Factor as a Radioprotectant for Gastrointestinal Injury Following Cancer Radiotherapy
LIF protects mice from Ionizing radiation:
survival is measured in control group without treatment (WT) vs. those treated with LIF (WT + LIF).
Invention Summary:
Currently there is no effective therapy for prevention or treatment of radiation therapy-induced gastrointestinal (GI) tract injury.
Rutgers researchers have recently discovered that...
Published: 12/8/2021
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Inventor(s): Wenwei Hu, Zhaohui Feng, Jianming Wang, Huaying Wang
Keywords(s): Anti-cancer, Gastrointestinal disease, Peptides
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Cancer, Technology Classifications > Therapeutics
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A New Method to Treat Asthma and Allergic Reaction
PBS PeptideIntranasal peptide treatment inhibits ILC2-dependent mucus productionInvention Summary:Although most patients with asthma respond to regular inhaled glucocorticoid (corticosteroid) therapy, 5% to 25% of people with asthma have more severe disease and do not respond...
Published: 12/8/2021
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Inventor(s): Mark Siracusa, Jacques Roberge
Keywords(s): Autoimmune, Peptides, Respiratory Disease
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Drug Candidate for the Treatment of Dilated Cardiomyopathy
Invention Summary: Dilated cardiomyopathy (DCM) is the most common cause of heart failure. About 5.7 million adults in the United States have heart failure, and approximately half million new cases are diagnosed annually. Patients with DCM can lead to arrhythmias, and about half of people who develop heart failure die within 5 years of diagnosis. Current...
Published: 12/8/2021
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Inventor(s): Diego Fraidenraich, Qingshi Zhao
Keywords(s): Cardiovascular, Peptides
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Oral Delivery of Therapeutics and Diagnostics using Peptide Ligands
Invention Summary:Intestinal uptake and absorption of orally administered drugs has been a challenge in the field of drug development and therapeutics research. Rutgers scientists have recently invented a novel mechanism to achieve increased absorption of molecules and to enhance their bioavailability via oral delivery. This invention facilitates the...
Published: 12/8/2021
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Inventor(s): Patrick Sinko
Keywords(s): Drug Delivery, Nanoparticles, Peptides
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Biomaterials, Technology Classifications > Therapeutics
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Methods to Produce Hepatitis C Virus E2 Protein
Invention Summary:Rutgers scientists have developed methods to produce and purify the ectodomain of HCV E2, a critical structural protein of the virus that has potential to serve as a vaccine candidate to prevent HCV infection. Efforts to study HCV, and to develop vaccines, have been impaired in part by the inability to produce sufficient quantities...
Published: 12/8/2021
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Inventor(s): Joseph Marcotrigiano, Jillian Whidby
Keywords(s): Drug Discovery/Screening, Peptides
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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