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Novel Cationic Amphiphiles Control Biofilm Formation for Bacterial Vaginosis
Cationic amphiphiles greatly inhibits the biofilm formation of the pathogenic bacteria in BV.Cationic Amphiphile Concentration (μM)Invention Summary:Bacterial vaginosis (BV) is a common polymicrobial infection in women of reproductive age, affecting 10-30% of women in developed nations. BV can lead to serious complications such as abortion, premature...
Published: 12/8/2021
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Inventor(s): Kathryn Uhrich, Allison Faig
Keywords(s): Antibacterial, Biofilm, Biomaterials, Drug Delivery, Personal Care, Cosmeceuticals, Polymers & Composites
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Biodegradable and Versatile Copolymers to Promote Wound Healing
Invention Summary:Rutgers scientists have developed a copolymer formulation to stably release salicylic acid (SA). It holds the promise for promoting topical and surgical wound healing, as SA is known to reduce local pain and inflammation as well as potentially prevent fibrous adhesion formation by reducing scar tissue. The release is stable over a...
Published: 12/8/2021
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Inventor(s): Kathryn Uhrich, Sabrina Snyder
Keywords(s): Biomaterials, Drug Delivery, Neurological disorder & neuropathic pain, Wound healing
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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PEG Nanocarriers, Nanogels
and Synthesis Methods
Invention Summary:
A novel platform of PEG-only nanocarriers and nanogels has been developed by Rutgers scientists. The nanocarriers can be used from 100Da-100- kDa and are capable of forming stable nanogels and nanogel aggregates in a variety of sizes from 20-30nm up to >1000nm. The carriers and gels have improved solubility over existing technologies...
Published: 12/8/2021
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Inventor(s): Patrick Sinko, Manjeet Deshmukh, Hilliard Kutscher, Stanley Stein, Simi Gunaseelan, Anupa Menjoge
Keywords(s): Biomaterials, Drug Delivery
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Biomaterials, Technology Classifications > Therapeutics
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A New Method to Enhance Lung Cancer Treatment
Summary:
Non-Small Cell Lung Carcinoma (NSCLC) is the most common type of lung cancer. Small molecule Tyrosine Kinase (TK) Inhibitors acting on the Epidermal Growth Factor Receptors (EGFRs) are standard therapies for patients with NSCLC harboring EGFR-TK inhibitor-sensitizing mutations. However, fewer than 10 % of patients with NSCLC benefit from...
Published: 12/8/2021
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Inventor(s): Tamara Minko, Olga Garbuzenko
Keywords(s): Drug Delivery, Nanoparticles, Nanotechnology
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Cancer, Technology Classifications > Nanotechnology
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Film Forming Foam (FFF) for Burn Wounds/Burnflex
Invention Summary:
Many of the available burn dressings on the market use latex, PVC or polyurethane as means of barrier-like components to protect the patient from outside elements. The current use of these components presents a problem of waste and contamination. Other available options in the market are hydrogel-based dressings that may...
Published: 12/8/2021
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Inventor(s): Maricely RamÃrez-Hernández, Tewodros Asefa, Jeffrey Boyd, Javiera Norambuena-Morales
Keywords(s): Antibacterial, Drug Delivery, Nanoparticles, Nanotechnology, Wound healing
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Nanotechnology, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Biomaterials, Technology Classifications > Consumer & Household Goods
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4D Printing of Microneedle Array for Enhanced Tissue Adhesion
Invention Summary:Microneedles are gaining attention because of the minimally invasive, pain-free, and easy-to-use nature. However, a major challenge for controlled long-term drug delivery or biosensing using microneedles is the low tissue adhesion.Rutgers researchers and collaborators have developed a method to fabricate microneedle array by a digital...
Published: 12/8/2021
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Inventor(s): Howon Lee, Giuseppe Barillaro, Riddish Morde, Emanuele Vignali
Keywords(s): Drug Delivery
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Medical Devices, Technology Classifications > Physical Sciences & Engineering
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Deposition of Microscale Coatings by Self-Limiting Electrospray
a. Overview of thickness-limited electrospray deposition (ESD). Electrostatically-driven spray creates a charged film which redirects charged incident droplets. b. and c. SEM images of spray results, illustrating the wide range of morphologies and particle size which can be obtained with this method(b: nanowires, c: hollow spheres).Invention Summary:...
Published: 12/8/2021
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Inventor(s): Jonathan Singer, Lin Lei
Keywords(s): Drug Delivery
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Polymers/Composites/Materials, Technology Classifications > COVID-19, Technology Classifications > Medical Devices, Technology Classifications > Vaccine
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A Platform Approach for Free Radical-Mediated Targeted Therapeutic Delivery
Invention Summary:Various pathological states including tissue injuries, inflammation, degenerative diseases and cancer are frequently associated with elevated free radicals, such as reactive oxygen and nitrogen species. These locally-generated free radicals are extremely reactive and are known to damage cells and tissues to exacerbate the pathology....
Published: 12/8/2021
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Inventor(s): David Shreiber, Christopher Lowe, Emily DiMartini, Adam Gormley
Keywords(s): Drug Delivery
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Versatile Biodegradable, Bioactive-Based Polymers for Topical, Cosmetic and Personal Care Applications
A. Structure of salicylic acid-based polymer and its degradation products.
B. Polymer degradation rates with different linker molecules.
C. Free ferulic acid in aqueous solution is unstable and turns brown after 10 days (left). Ferulic acid-based polymers are stable and aesthetically more pleasing in solution under the same condition (right).
Invention...
Published: 12/8/2021
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Inventor(s): Kathryn Uhrich, Jonathan Faig, Kervin Smith
Keywords(s): Antibacterial, Biomaterials, Drug Delivery, Personal Care, Cosmeceuticals, Polymers & Composites
Category(s): Technology Classifications > Healthcare & Life Sciences
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Molecular Assays for Identification of Echinocandin Resistant Fungi
Representative melting profiles for C. Glabrata after amplification of clinical isolates A) FKS1 HS1 primers B) FKS2 HS1 primers. DNA sequencing was used to confirm predicted genotypes (indicated by markers)Invention Summary:Fungal infections are as significant cause of mortality and morbidity when not rapidly diagnosed and treated. Echinocandin antifungal...
Published: 12/8/2021
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Inventor(s): David Perlin, Steven Park
Keywords(s): Drug Delivery
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics
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