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Biosensor for Therapeutic Drug Monitoring of Fungal Drugs
Aptamer-based GFET devices show a detectable threshold Dirac voltage shift between 0.1 mg/mL and 0.1 µg/mL with posconazole, but no shift with caspofungin (echinocandin).Invention Summary: To safely and effectively treat patients with anti-fungal drugs, physicians must understand the pharmacokinetics (PK) of those drugs In patients. However, the...
Published: 12/8/2021
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Inventor(s): David Perlin, Gregory Weidman, Yanan Zhao
Keywords(s): Biosensor
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics
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Small Molecule Fluorescent Probe
Sensitivity of detection method with ROC, comparison of NIR probe with conventionalInvention Summary: Fluorophores in the near infrared (NIR) range, where body tissue is transparent, are promising alternatives to radioactive labels. Conjugation of NIR dyes to targeting agents enables specific detection of molecules of interest. However, conventional...
Published: 12/8/2021
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Inventor(s): Arkady Mustaev, David Perlin, Laura Wirpsza
Keywords(s): Drug Discovery/Screening
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Research Tools
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Fluorescent Detection of Fungal Pathogens
Mice infected intrastromally with three different strains of Aspergillus (A. fumigatus, A. flavus, A. niger). Labeling of infected area using caspofungin-conjugated fluorescent probe.Invention Summary: Diagnostic imaging could provide important spatial information about fungal infections, but current imaging modalities lack specificity for fungal pathogens....
Published: 12/8/2021
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Inventor(s): David Perlin, Guillermo Garcia-Effron, Arkady Mustaev
Keywords(s): Sensors & Probes
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Research Tools, Technology Classifications > Diagnostics
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Rapid Molecular Assays for Fungal Infections
Sensitivity of real-time NASBA assay for fungi. B: pan-Candida probe, C: pan-Aspergillus probeInvention Summary: Fungal infections are as significant cause of mortality and morbidity when not rapidly diagnosed and treated. However, the current standard of care for diagnosis is blood culture, a method limited by the time to diagnosis (1-2 days), frequency...
Published: 12/8/2021
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Inventor(s): David Perlin, Steven Park, David Denning
Keywords(s): Biomarkers
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics
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Molecular Assays for Identification of Echinocandin Resistant Fungi
Representative melting profiles for C. Glabrata after amplification of clinical isolates A) FKS1 HS1 primers B) FKS2 HS1 primers. DNA sequencing was used to confirm predicted genotypes (indicated by markers)Invention Summary:Fungal infections are as significant cause of mortality and morbidity when not rapidly diagnosed and treated. Echinocandin antifungal...
Published: 12/8/2021
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Inventor(s): David Perlin, Steven Park
Keywords(s): Drug Delivery
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics
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