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High-throughput Nanoarray Screening Platform for Multi-Cellular Applications
Scope of the combinatorial nanoarray cell screening platform – varying parameters can all be contained in the CBC array to match the complexity of natural ECMs and biophysical cues.
Invention Summary:
Biophysical cues mediated by natural or synthetic extracellular matrices (ECMs) play an essential role in cellular reprogramming....
Published: 12/8/2021
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Inventor(s): Ki-Bum Lee, Letao Yang
Keywords(s): Biosensor
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Nanotechnology
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Dual-Enhanced Raman Scattering-Based Nanoarray Biosensors
A schematic showing graphene-gold hybrid nanoarray for nucleic acid detection and cellular biosensing
Invention Summary:
Raman spectroscopy is a nondestructive, label-free technique that uses laser light to discriminate cell and tissue types. While Surface enhanced Raman scattering (SERS) has demonstrated great potential to analyze a variety of bio/chemical...
Published: 7/28/2022
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Inventor(s): Ki-Bum Lee, Letao Yang
Keywords(s): Biosensor
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics
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One-Step Exosome Isolation and Detection
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Extract and concentrate exosomes immunomagnetically, analyze exosomal miRNA sensitively via metal-enhanced fluorescence effect.
Invention Summary:
Exosomes and their inner contents play critical roles in intercellular communication and signaling. The use of exosomes as next-generation biomarkers...
Published: 12/8/2021
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Inventor(s): Ki-Bum Lee, Jin-Ho Lee
Keywords(s): Biosensor
Category(s): Technology Classifications > Polymers/Composites/Materials, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics
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CerebroSense: A Brain Pulsatility Measurement Device
Invention Summary:During craniotomy, surgeons often determine the level of brain swelling based on finger tactile sensation in order to implement compensation measurements. However, under or over compensation can lead to severe complications such as cerebral ischemia. Researchers at Rutgers University and Stevens Institute of Technology have developed...
Published: 12/8/2021
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Inventor(s): Glen Atlas, Maria Pineda, David Ferrara, Andrew Falcone, Vikki Hazelwood
Keywords(s): Biosensor
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Medical Devices
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Nanowell Array Sensor Chip for Biosensing in Blood Samples
Entire multiwell plate chip and a schematic view of the 2-μm nanowell array sensor. The sensor is comprised of an array of 25 nanowells etched on the overlapping electrode surface.
Invention Summary:
The current gold-standard for protein quantification in laboratory tests is enzyme linked immunosorbent assay (ELISA), which typically relies on...
Published: 7/28/2022
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Inventor(s): Mehdi Javanmard, Pengfei Xie, Mark Allen, Wen Shen, Naixin Song
Keywords(s): Biosensor, Immunoassay
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Medical Devices, Technology Classifications > Diagnostics, Technology Classifications > COVID-19, Technology Classifications > Healthcare & Life Sciences
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Biosensor for Therapeutic Drug Monitoring of Fungal Drugs
Aptamer-based GFET devices show a detectable threshold Dirac voltage shift between 0.1 mg/mL and 0.1 µg/mL with posconazole, but no shift with caspofungin (echinocandin).Invention Summary: To safely and effectively treat patients with anti-fungal drugs, physicians must understand the pharmacokinetics (PK) of those drugs In patients. However, the...
Published: 12/8/2021
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Inventor(s): David Perlin, Gregory Weidman, Yanan Zhao
Keywords(s): Biosensor
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics
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Portable Exhaled Breath Condensate (EBC) Analyzer for Asthma Diagnosis and Monitoring
Invention Summary: Asthma, an increasingly important global health problem that affects ~ 300 million people worldwide, is characterized by variable airway inflammation and air flow obstruction. Currently available non-invasive methods for diagnosing and monitoring asthma involve measurements of exhaled nitric oxide (NO). Apart from the transient nature...
Published: 12/8/2021
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Inventor(s): Mehdi Javanmard, Azam Gholizadeh, Robert Laumbach, Howard Kipen, Clifford Weisel, Manish Chhowalla, Andrew Gow, Damien Voiry
Keywords(s): Biosensor, Electronics
Category(s): Technology Classifications > Medical Devices, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics
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Biosensors for Real-Time Antimicrobial Susceptibility Testing
(A) A schematic of the biosensor. (B) Real time detection of the effect of antibiotics (Ampicillin) on the growth of E. coli. (C) and (D) Real time detection of the effect of antifungal agents Miconazole and Amphotericin B on the growth of yeast.
Invention Summary:
Antimicrobial resistance (AMR) is becoming a major global-health concern. Traditional...
Published: 7/28/2022
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Inventor(s): Yicheng Lu, Pavel Reyes, Steven Zheng, Andrew Zheng, Keyang Yang
Keywords(s): Biosensor
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics, Technology Classifications > Research Tools, Technology Classifications > Electronics/Semiconductor, Technology Classifications > Infectious Disease
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Novel Quantitative & Objective Analytical Tool for Detecting Neurodevelopmental Delays in Infants
Invention Summary: Neurodevelopmental disorders (e.g. autism) are on the rise. They are the byproduct of a lengthy maturation process that starts at conception and manifests disarray with high certainty during infancy, when dysfunction of the child’s nervous systems becomes apparent to the naked eye. By three years of age, observational diagnoses...
Published: 12/8/2021
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Inventor(s): Elizabeth Torres
Keywords(s): Autism, Biosensor, Neurological disorder & neuropathic pain
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics
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Nanoelectronic Barcoding of Microparticles for Multiplexed Molecular Analysis
Invention Summary: Capability of detecting multiple protein and nucleic acid biomarkers is crucial to disease diagnosis and precision medicine. Barcoding of microparticles is one of the most common approaches for enabling multiplexed molecular assays. Although optical and plasmonic methods for barcoding particles have been developed, instrumentations...
Published: 12/8/2021
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Inventor(s): Mehdi Javanmard
Keywords(s): Biosensor, Immunoassay
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics
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