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High-throughput Nanoarray Screening Platform for Multi-Cellular Applications
Scope of the combinatorial nanoarray cell screening platform – varying parameters can all be contained in the CBC array to match the complexity of natural ECMs and biophysical cues.
Invention Summary:
Biophysical cues mediated by natural or synthetic extracellular matrices (ECMs) play an essential role in cellular reprogramming....
Published: 12/8/2021
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Inventor(s): Ki-Bum Lee, Letao Yang
Keywords(s): Biosensor
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Nanotechnology
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Rapid Cell Assembly for 3D Culture
A. Schematic diagram showing the self-assembly of a spheroid.
B. Schematic showing transplantation of spheroids for the repair/regeneration of spinal cord
Invention Summary:
3D cell culture including organoid and spheroid cultures is at the center stage of biomedical research. It is widely applied in organ development research, disease modeling,...
Published: 12/8/2021
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Inventor(s): Ki-Bum Lee
Keywords(s): Bioengineering scaffolds, Tissue Engineering
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Research Tools
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Dual-Enhanced Raman Scattering-Based Nanoarray Biosensors
A schematic showing graphene-gold hybrid nanoarray for nucleic acid detection and cellular biosensing
Invention Summary:
Raman spectroscopy is a nondestructive, label-free technique that uses laser light to discriminate cell and tissue types. While Surface enhanced Raman scattering (SERS) has demonstrated great potential to analyze a variety of bio/chemical...
Published: 7/28/2022
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Inventor(s): Ki-Bum Lee, Letao Yang
Keywords(s): Biosensor
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics
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One-Step Exosome Isolation and Detection
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Extract and concentrate exosomes immunomagnetically, analyze exosomal miRNA sensitively via metal-enhanced fluorescence effect.
Invention Summary:
Exosomes and their inner contents play critical roles in intercellular communication and signaling. The use of exosomes as next-generation biomarkers...
Published: 12/8/2021
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Inventor(s): Ki-Bum Lee, Jin-Ho Lee
Keywords(s): Biosensor
Category(s): Technology Classifications > Polymers/Composites/Materials, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics
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Scaffold-Free Biological Assemblies for Tissue Modeling and Regeneration
Invention Summary:The evolution of in vitro-engineered scaffold-free tissues for tissue modeling and regenerative medicine has been driven by the need to recapitulate the cellular organization of endogenous tissues and to avoid undesired scaffold-related side effects upon implantation. Methods to produce scaffold-free tissue or cell assemblies have...
Published: 12/8/2021
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Inventor(s): Ki-Bum Lee, Letao Yang
Keywords(s): Bioengineering scaffolds, Tissue Engineering, Wound healing
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Cell Therapy, Technology Classifications > Therapeutics
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Spatial Dopant Separation using Core-Shell Architecture For Upconversion Luminescent Enhancement in the Erbium-Doped System
Invention Summary:
Upconversion nanoparticles (UCNPs) have gained increasing attention for various biomedical applications due to their high photostability, low autofluorescent background, and deep tissue penetration; however, UCNPs also suffer from low emission intensities due to undesirable energy back-transfer. Further, the use of high-power density...
Published: 7/28/2022
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Inventor(s): Ki-Bum Lee, Hudifah Rabie, Nicholas Pasquale
Keywords(s): Imaging, Sensors & Probes
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Nanotechnology, Technology Classifications > Medical Imaging
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Versatile CRISPR-Cas9 Gene Editing System
Successful gene editing in neurons differentiated from patient-derived neural stem cells. Left panel, gene editing using control guide RNA; Right panel, gene editing using MeCP2 guide RNA.
Summary:
CRISPR-Cas-mediated genome editing makes effective gene therapy of human disease feasible. Although viral delivery of CRISPR-Cas...
Published: 12/8/2021
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Inventor(s): Ki-Bum Lee, Hyeon-Yeol Cho, Myung-Sik Yoo
Keywords(s): Gene editing
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Rare Disease, Technology Classifications > Therapeutics
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Biodegradable Scaffold for Advanced Stem Cell Therapy
Schematic diagram representing the self assembly of Laminin (ECM) and the MnO2 sheet
Invention Summary:
While regenerative stem cell therapy has been a promising approach for transplant medicine and surgery, there have been challenges due to low transplantation survival rate and poor selectivity in differentiation.
Researchers at Rutgers University...
Published: 7/28/2022
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Inventor(s): Ki-Bum Lee, Letao Yang
Keywords(s): Bioengineering scaffolds, Biomaterials, Tissue Engineering
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Biomaterials, Technology Classifications > Therapeutics
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Graphene-Encapsulated Nanoparticle-Based Biosensor for Biomarker Detection and Its Use in Early Diagnosis of Cancer, HIV and Other Diseases
Device SchematicInvention Summary:The detection of biomarker proteins with high sensitivity and selectivity is vital for the early diagnosis of many diseases such as cancer and HIV. Rutgers scientists have developed a reduced graphene oxide encapsulated nanoparticle (rGO-NPs)-based field effect transistor (FET) biosensor for sensitive detection of key...
Published: 12/8/2021
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Inventor(s): Ki-Bum Lee, Sung Myung, Aniruddh Solanki
Keywords(s): Biosensor
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Research Tools, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Nanotechnology
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NanoScript – Nanoparticle-based Synthetic Transcription Factor for Therapeutic Gene Modulation
Invention Summary:
Since its introduction over two decades ago, the advancement of synthetic transcription factors has faced significant challenges, including poor membrane penetration, intracellular degradation, limited nuclear localization, low gene activation, and low synthesis efficiency.
Rutgers scientists have developed a novel synthetic...
Published: 12/8/2021
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Inventor(s): Ki-Bum Lee, Sahishnu Patel
Keywords(s): Drug Delivery
Category(s): Technology Classifications > Research Tools, Technology Classifications > Therapeutics, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences
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