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dCas9 Protein Allele Sequestration for Improved CRISPR Gene Editing
Invention Summary:
CRISPR technology is widely used in research to edit genes
in animals and cell lines and is moving towards therapeutic use in the clinic. Inherent to almost all methods employed in gene editing is the lack of control in target gene usage. A method to direct cleavage of only a single target within a cell would be beneficial to research...
Published: 12/8/2021
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Inventor(s): Peter Romanienko, Ghassan Yehia
Keywords(s): Gene editing
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Gene Therapy, Technology Classifications > Research Tools
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Versatile CRISPR-Cas9 Gene Editing System
Successful gene editing in neurons differentiated from patient-derived neural stem cells. Left panel, gene editing using control guide RNA; Right panel, gene editing using MeCP2 guide RNA.
Summary:
CRISPR-Cas-mediated genome editing makes effective gene therapy of human disease feasible. Although viral delivery of CRISPR-Cas...
Published: 12/8/2021
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Inventor(s): Ki-Bum Lee, Hyeon-Yeol Cho, Myung-Sik Yoo
Keywords(s): Gene editing
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Rare Disease, Technology Classifications > Therapeutics
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Treatment for Neuropsychiatric Disorders by Intravitreal Injection of DREADD Followed by Eye Drops or Pills Containing DREADD agonist
Figure 1. DREADD receptor-mediated activation of retinal cells prevents the development of light deprivation-induced depression-like behavior in vivo. A. DD-hM3Dq activation prevents the relative weight loss that was induced by constant dark lighting conditions. B. DREADD receptor-mediated activation of retinal cells leads to a reduction of depression-like...
Published: 12/8/2021
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Inventor(s): Gary Aston-Jones, Hannah Bowrey
Keywords(s): Gene editing, Neurological disorder & neuropathic pain
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Lightning-fast Genome Variant Detection
Summary:
Current human whole genome sequencing projects produce massive amounts of data, often creating significant computational challenges. Different approaches have been developed for each type of genome variant and method of detection, necessitating users to run multiple algorithms to find variants.
Researchers at Rutgers University have developed...
Published: 12/8/2021
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Inventor(s): Andrey Grigoriev, Sean Smith
Keywords(s): Bioinformatics, Gene editing
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Software & Copyright, Technology Classifications > Software & Algorithms
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