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Novel ChABC formulation with machine learning-guided automation
Invention Summary:
Spinal cord injury (SCI) leads to the formation of scar tissue. The scarring leads to the toughening of the extracellular matrix, or the cellular environment. One of the major concerns of SCI is the prevention of neuronal connection recovery, which can lead to paralysis or reduced control of the nervous system. For...
Published: 8/18/2022
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Inventor(s): Adam Gormley, Matthew Tamasi, Shashank Kosuri, Michael Webb, Carlos Borca, Roshan Patel
Keywords(s): Biomaterials, Polymers & Composites, Proteins, Spinal Cord
Category(s): Technology Classifications > Biomaterials, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Polymers/Composites/Materials, Technology Classifications > Software & Algorithms, Technology Classifications > Therapeutics
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Novel Cationic Amphiphiles Control Biofilm Formation for Bacterial Vaginosis
Cationic amphiphiles greatly inhibits the biofilm formation of the pathogenic bacteria in BV.Cationic Amphiphile Concentration (μM)Invention Summary:Bacterial vaginosis (BV) is a common polymicrobial infection in women of reproductive age, affecting 10-30% of women in developed nations. BV can lead to serious complications such as abortion, premature...
Published: 12/8/2021
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Inventor(s): Kathryn Uhrich, Allison Faig
Keywords(s): Antibacterial, Biofilm, Biomaterials, Drug Delivery, Personal Care, Cosmeceuticals, Polymers & Composites
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Biodegradable and Versatile Copolymers to Promote Wound Healing
Invention Summary:Rutgers scientists have developed a copolymer formulation to stably release salicylic acid (SA). It holds the promise for promoting topical and surgical wound healing, as SA is known to reduce local pain and inflammation as well as potentially prevent fibrous adhesion formation by reducing scar tissue. The release is stable over a...
Published: 12/8/2021
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Inventor(s): Kathryn Uhrich, Sabrina Snyder
Keywords(s): Biomaterials, Drug Delivery, Neurological disorder & neuropathic pain, Wound healing
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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PEG Nanocarriers, Nanogels
and Synthesis Methods
Invention Summary:
A novel platform of PEG-only nanocarriers and nanogels has been developed by Rutgers scientists. The nanocarriers can be used from 100Da-100- kDa and are capable of forming stable nanogels and nanogel aggregates in a variety of sizes from 20-30nm up to >1000nm. The carriers and gels have improved solubility over existing technologies...
Published: 12/8/2021
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Inventor(s): Patrick Sinko, Manjeet Deshmukh, Hilliard Kutscher, Stanley Stein, Simi Gunaseelan, Anupa Menjoge
Keywords(s): Biomaterials, Drug Delivery
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Biomaterials, Technology Classifications > Therapeutics
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Cationic Amphiphile for Antimicrobial Applications
The structure of CAms 5a, 5b, 5c, 8a, 8b, and 8c
Invention Summary:
The development of antibiotic-resistant bacteria is a prevalent concern that has prompted the development of new antimicrobial agents. Naturally-occurring antimicrobial peptides (AMPs) offer advantages over conventional antibiotics due to a reduced development of resistance...
Published: 12/8/2021
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Inventor(s): Kathryn Uhrich, Yingyue Zhang, Allison Faig, Michael (mikhail) Chikindas
Keywords(s): Antibacterial, Biomaterials, Peptides
Category(s): Technology Classifications > Therapeutics, Technology Classifications > Healthcare & Life Sciences
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Fine-Tune Cellulose Crystals in Biocomposites
Morphology change from crystalline (I. Pure Cellulose) to amorphous (III. coagulated in water) or semi-crystalline (IV. coagulated in H2O2) Invention Summary:Natural materials such as cellulose or silk can be used in a multitude of applications such as electrolyte batteries, filters, drug delivery systems and scaffolds for tissue engineering. Transforming...
Published: 12/8/2021
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Inventor(s): David De La Cruz, Xiao Hu, Stacy Love, David Verrill
Keywords(s): Biomaterials, Chemical and petrochemical industry, Membranes, Nanotechnology
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Polymers/Composites/Materials
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Biodegradable Scaffold for Advanced Stem Cell Therapy
Schematic diagram representing the self assembly of Laminin (ECM) and the MnO2 sheet
Invention Summary:
While regenerative stem cell therapy has been a promising approach for transplant medicine and surgery, there have been challenges due to low transplantation survival rate and poor selectivity in differentiation.
Researchers at Rutgers University...
Published: 7/28/2022
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Inventor(s): Ki-Bum Lee, Letao Yang
Keywords(s): Bioengineering scaffolds, Biomaterials, Tissue Engineering
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Biomaterials, Technology Classifications > Therapeutics
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Biomimetic, Bioactive Dental Implants
Left: 3D printed mold; Center: prototype bioactive implant; Right: prototype lateral incisor implant restored with acrylic temporary crown (after implantation).Invention Summary: While titanium dental implants are the current state of the art for tooth replacement, they involve an invasive surgical procedure and significant risks. Aside from intraoperative...
Published: 12/8/2021
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Inventor(s): Amir Fakhrzadeh
Keywords(s): Bioengineering scaffolds, Biomaterials, Implants, Polymers & Composites
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Biomaterials, Technology Classifications > Medical Devices, Technology Classifications > Dental, Technology Classifications > Polymers/Composites/Materials
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Thermo-Activated Lubricant Additives for Improving Engine Efficiency and Fuel Economy
Controlled Release Friction Reduction over TimeInvention Summary:Friction modifiers (FMs) have been extensively studied as lubricant additives that could improve lubricity of base oil friction profiles to enhance fuel economy by the petrochemical and automobile industries. There are two classes of FMs, the ash FM (organo-molybdenum molecules) and ashless...
Published: 12/8/2021
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Inventor(s): Kathryn Uhrich, Jonathan Faig, Yingyue Zhang, Shuji LUO, Man KIT NG, Alan SCHILOWITZ, Anne SHOUGH
Keywords(s): Biomaterials, Chemical and petrochemical industry
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Polymers/Composites/Materials
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Versatile Biodegradable, Bioactive-Based Polymers for Topical, Cosmetic and Personal Care Applications
A. Structure of salicylic acid-based polymer and its degradation products.
B. Polymer degradation rates with different linker molecules.
C. Free ferulic acid in aqueous solution is unstable and turns brown after 10 days (left). Ferulic acid-based polymers are stable and aesthetically more pleasing in solution under the same condition (right).
Invention...
Published: 12/8/2021
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Inventor(s): Kathryn Uhrich, Jonathan Faig, Kervin Smith
Keywords(s): Antibacterial, Biomaterials, Drug Delivery, Personal Care, Cosmeceuticals, Polymers & Composites
Category(s): Technology Classifications > Healthcare & Life Sciences
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