Search Results - raymond+birge

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Novel Phosphatidylserine-Targeting Immunobiologicals for Cancer and Viral Treatment PS-targeting biological inhibits tumor growth and virus infection Invention Summary: Phosphatidylserine (PS) is a phospholipid that is restricted to the inner plasma membrane in healthy cells but is externalized in apoptotic or stressed cells abundantly present in tumor microenvironment or in sites of virus infection. PS is also present on the surface... Published: 12/8/2021   |   Inventor(s): Sergei Kotenko, Viralkumar Davra, Raymond Birge Keywords(s): Anti-cancer, Antiviral Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics

Small Molecule Extracellular Inhibitors of TAM Receptors for Cancer Therapy Invention Summary:The TAM receptors (Tyro3, Axl, and Mertk) are a family of three homologous receptor tyrosine kinases (RTKs) that play important roles in tissue homeostasis, immune response, and the resolution of inflammation. Besides the intracellular catalytic kinase domain common to all kinases, the TAMs uniquely contain an extracellular domain... Published: 12/8/2021   |   Inventor(s): William Welsh, Raymond Birge, Vladyslav Kholodovych, Youyi Peng, Stanley Kimani, Thomas Comollo Keywords(s): Anti-cancer, Brain Cancer, Breast Cancer, Cancer biomarkers Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics