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Therapeutics for Tuberculosis: Novel Inhibitors of Mycobacterial RNA Polymerase
Invention Summary:Tuberculosis kills nearly 2 million persons each year. One third of the world's population currently is infected with tuberculosis, and the World Health Organization projects that there will be nearly 1 billion new infections by 2020, 200 million of which will result in serious illness, and 35 million of which will result in death....
Published: 12/8/2021
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Inventor(s): Richard Ebright, Yon Ebright, Soma Mandal
Keywords(s): Antibacterial
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Therapeutics for Drug-Resistant Bacterial Infections: Inhibitors of Bacterial RNA Polymerase
Invention Summary:Bacterial infectious diseases kill 100,000 persons each year in the US and 11 million persons each year worldwide, representing nearly a fifth of deaths each year worldwide. For six decades, antibiotics have been our bulwark against bacterial infectious diseases. However, now this bulwark is collapsing. For all major bacterial pathogens,...
Published: 12/8/2021
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Inventor(s): Richard Ebright, Yu Feng, Yu Zhang
Keywords(s): Antibacterial
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Therapeutics for Drug-Resistant Bacterial Infections - Myxopyronins
Invention Summary:There is an urgent national and international need for new classes of antibacterial agents effective against bacterial pathogens resistant to current antibacterial agents.Myxopyronin (Myx) is a microbially produced antibiotic that inhibits bacterial RNA polymerase through a novel binding site and novel mechanism. Rutgers researchers...
Published: 12/8/2021
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Inventor(s): Richard Ebright, Juan Shen, James Bacci, William Solvible, Christopher Self, Gary Olson, Yon Ebright, Anne-Cecile Hiebel
Keywords(s): Antibacterial
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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