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SAHMI: Microbiome-based screening method for cancer and other diseases
Screening methodology and principle data identifying differences in
microbiome diversity from disease state in pancreatic cancer
Invention Summary:
The microbiome plays an essential role in the prognosis and progression of disease and health, as seen in cancers like pancreatic cancer. Pancreatic cancer is rising in majority of cancer...
Published: 7/28/2022
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Inventor(s): Subhajyoti De, Bassel Ghaddar
Keywords(s): Anti-cancer, Bioinformatics, Biomarkers, Cancer biomarkers
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics, Technology Classifications > Cancer
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Biomarkers for Identifying Patients at High Risk of Progressing
from Barrett’s Esophagus to Esophageal Adenocarcinoma
Invention Summary:
Esophageal adenocarcinoma (EAC) has a poor prognosis with a 5-year overall survival of 15-20%. In the past 3 decades, the incidence of EAC increased 600-800%. Barrett’s esophagus (BE), the precancerous lesion for EAC, has approximately 0.11 to 1.6% annual rate of progression to EAC. Currently, the guidelines for BE surveillance...
Published: 12/8/2021
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Inventor(s): Zhongren ("David") Zhou
Keywords(s): Anti-cancer, Biomarkers, Cancer biomarkers
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics, Technology Classifications > Cancer
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JNK Inhibitor that Prevents Chemotherapy-induced Premature Ovarian Failure
JNK Inhibitor SP600125 prevented DOX-induced Primordial Follicle Loss
Invention Summary:
Premature ovarian failure (POF) is a disease characterized by the depletion of primordial follicles in women’s ovaries before the age of 40, and is a major side effect of chemotherapy in childhood-age, adolescent and young adult female cancer patients....
Published: 7/28/2022
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Inventor(s): Shuo Xiao
Keywords(s):
Category(s): Technology Classifications > Cancer
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A Method to Predict the Response of Individual Patient to Cocktails of Radiopharmaceuticals, Chemotherapeutics or Other Agents
Representative pictures showing wide variation in cellular uptake of radiopharmaceuticals.
Invention Summary:
A number of therapeutic cocktails have been developed to treat various diseases including metastatic cancers. However, patients vary widely in their beneficial responses to such therapies. It has been found that the uptake of targeted therapeutic...
Published: 12/8/2021
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Inventor(s): Roger Howell, Behrooz Vaziri, Han Wu, Atam Dhawan
Keywords(s): Antibodies, Anti-cancer
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Cancer, Technology Classifications > Software & Algorithms, Technology Classifications > Software & Copyright
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Method to Predict the Response of Individual Patient to Cocktails of Radiopharmaceuticals, Chemotherapeutics, or Other Agents
Representative pictures showing wide variation in cellular uptake of radiopharmaceuticals.
Invention Summary:
A number of therapeutic cocktails have been developed to treat various diseases including metastatic cancers. However, patients vary widely in their beneficial responses to such therapies. It has been found that the uptake of targeted therapeutic...
Published: 12/8/2021
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Inventor(s): Roger Howell, Jordan Pasternack, John Akudugu
Keywords(s): Antibodies, Anti-cancer
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Cancer
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A New Method to Enhance Lung Cancer Treatment
Summary:
Non-Small Cell Lung Carcinoma (NSCLC) is the most common type of lung cancer. Small molecule Tyrosine Kinase (TK) Inhibitors acting on the Epidermal Growth Factor Receptors (EGFRs) are standard therapies for patients with NSCLC harboring EGFR-TK inhibitor-sensitizing mutations. However, fewer than 10 % of patients with NSCLC benefit from...
Published: 12/8/2021
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Inventor(s): Tamara Minko, Olga Garbuzenko
Keywords(s): Drug Delivery, Nanoparticles, Nanotechnology
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Cancer, Technology Classifications > Nanotechnology
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New Vector Platform for Concurrent Tumor Imaging, Therapy, and Evaluation of Response to Therapy
Diagnosis of HER2+ cancer metastasis lesions in mouse using a genetically engineered targeted vector in conjunction with MRI. The MRI followed by voxel-by-voxel analysis of scans showed that the vector makes it possible to differentiate HER2+ from HER2- cancer lesions in mouse lungs
Invention Summary:
The human epidermal growth factor receptor-2...
Published: 12/8/2021
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Inventor(s): Arash Hatefi
Keywords(s): Breast Cancer
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Cancer
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Predicting Therapeutic Resistance to Tamoxifen in Cancer Treatment
Summary:
Currently, patients with ER+ breast cancer are administered tamoxifen without considering their potential response to this therapy. Thousands of women take the tamoxifen only to discover that their tumors do not respond or that they develop resistance over time. The ability to screen patients ahead of the therapy administration can improve...
Published: 12/8/2021
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Inventor(s): Antonina Mitrofanova, Sarra Rahem
Keywords(s): Bioinformatics, Breast Cancer, Data Science, Digital Health
Category(s): Technology Classifications > Software & Copyright, Technology Classifications > Software & Algorithms, Technology Classifications > Diagnostics, Technology Classifications > Cancer, Technology Classifications > Healthcare & Life Sciences
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CAR-T and CAR-NK Immunotherapy for Hepatocellular Carcinoma
CAR-NK cells control progression of HCC in PDX modelInvention Summary:Chimeric antigen receptor (CAR)-modified T cell therapy has become a promising immune-therapeutic strategy for the treatment of various blood cancers. Hepatocellular carcinoma (HCC) is the most common type of cancer that starts in the liver. HCC is the third most common cause of cancer-related...
Published: 12/8/2021
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Inventor(s): Dongfang Liu, Mustafa Mozael
Keywords(s): Anti-cancer, Bioengineering scaffolds
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Cancer
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A Novel Approach for Expansion of NK and CAR-modified NK Cells
Fold expansion of NK cells from cord blood expanded with irradiated K562-mIL21 and RU-Feeder CellsInvention Summary:Chimeric antigen receptor T-cell immunotherapy (CAR-T cell therapy) requires engineering of T cells harvested from the patient. Natural killer (NK) cells are also cytotoxic immune cells, but work somewhat differently from T cell. Engineered...
Published: 12/8/2021
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Inventor(s): Dongfang Liu
Keywords(s): Anti-cancer, Cell Lines
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Cancer, Technology Classifications > Cell Therapy
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