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Novel System for High-Yield Production of Proteins and Protein Domains
Invention Summary:The synthesis of recombinant proteins using prokaryotic expression systems has been instrumental in producing valuable reagents for biomedical research and commercial products. However, the majority of in vivo expression systems have inherent limitations in most applications – including low yields, poor quality of the expressed...
Published: 12/8/2021
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Inventor(s): Gaetano Montelione, Stephen Anderson, Yuanpeng Huang, Thomas Acton
Keywords(s): Drug Discovery/Screening, Manufacturing, Peptides
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Research Tools
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Fluorescent Probe for Bacterial Cell Imaging and Screening of New Antibacterial Drugs
Visualization of the impact of FtsZ-targeting drug treatment in both Gram-positive and Gram-negative bacterial strains using BOFP. Bacteria were labeled with BOFP for 5 minutes just prior to visualization. Differential interference contrast (DIC) shows unstained bacteria and fluorescence shows BOFP-labeled bacteria.Invention Summary:At least 2.8 million...
Published: 12/8/2021
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Inventor(s): Daniel Pilch, Edgar Ferrer-Gonzalez, Edmond LaVoie
Keywords(s): Drug Discovery/Screening
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Infectious Disease, Technology Classifications > Research Tools
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Novel Array Insert for One-Step 3D Cultures and Histological Processing
Schematic diagram of the technology. Organoid cultures can be grown in a basket array the size of a 96-well plate. The array can be shrunk down to fit into a histology cassette without need to transfer the culture.Invention Summary:Organoids are multicellular 3D structures that faithfully mimic their in vivo organ counterparts and are valuable tools...
Published: 12/8/2021
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Inventor(s): Hatem Sabaawy, Howon Lee, Chen Yang, Daehoon Han
Keywords(s): Drug Discovery/Screening
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Research Tools, Technology Classifications > Healthcare & Life Sciences
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Human Normal and Cancer Organoid Culture with Defined Components for Six Different Tissue Types
Invention Summary:An organoid is a small three-dimensional (3-D) cellular tissue structure that highly resembles the in-vivo organ from which it is originated. New technology developed at Rutgers Cancer Institute of New Jersey enables researchers to generate organoids from six different cancer types and normal tissues derived from patients suffering...
Published: 12/8/2021
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Inventor(s): Hatem Sabaawy
Keywords(s): Anti-cancer, Drug Discovery/Screening
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Research Tools
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Novel Ricin Inhibitors
(A) Model showing the interaction of Ricin toxin A (RTA) with the P stalk to access the sarcin/ricin loop (SRL) of the eukaryotic ribosome. 26S rRNA and 60S subunit are shown in light gray and dark gray, respectively. (B) The 50% inhibitory concentration (IC50) of fragments against RTA.
Invention Summary:
Ricin toxin is lethal to human at small doses,...
Published: 12/8/2021
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Inventor(s): Nilgun Tumer, Xiao-Ping Li
Keywords(s): Drug Discovery/Screening
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Small Molecule Fluorescent Probe
Sensitivity of detection method with ROC, comparison of NIR probe with conventionalInvention Summary: Fluorophores in the near infrared (NIR) range, where body tissue is transparent, are promising alternatives to radioactive labels. Conjugation of NIR dyes to targeting agents enables specific detection of molecules of interest. However, conventional...
Published: 12/8/2021
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Inventor(s): Arkady Mustaev, David Perlin, Laura Wirpsza
Keywords(s): Drug Discovery/Screening
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Research Tools
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In Vitro Model of Liver Steatosis for Screening of Drug Compounds
The decrease in liver steatosis in hepatocytes cultured in steatosis reducing medium.Invention Summary: Donor livers are frequently rejected due to high intracellular fat content, called steatosis, which increases the risk of primary graft non-function in transplant patients. Because liver transplantation remains the only effective treatment for end-stage...
Published: 12/8/2021
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Inventor(s): Martin Yarmush, Nir Nativ, Francois Berthiaume, Gabriel Yarmush, Timothy Maguire, Rene Schloss
Keywords(s): Drug Discovery/Screening
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Research Tools
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Human Normal and Cancer Organoid Culture with Defined Components for Six Different Tissue Types
Invention Summary:An organoid is a small three-dimensional (3-D) cellular tissue structure that highly resembles the in-vivo organ from which it is originated. New technology developed at Rutgers Cancer Institute of New Jersey enables researchers to generate organoids from six different cancer types and normal tissues derived from patients suffering...
Published: 12/8/2021
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Inventor(s): Hatem Sabaawy, Monica Bartucci
Keywords(s): Drug Discovery/Screening
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics
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A Humanized Yeast System for mTOR Kinase Inhibitor Screening and Studies
Invention Summary:mTOR kinase is a highly conserved central regulator of cell growth and metabolism, and a key cancer drug target. Numerous mTOR kinase inhibitors have been developed but have not been approved by FDA. A new screening tool for mTOR kinase inhibitors will facilitate mTOR therapeutic development and related pharmacology studies. Rutgers...
Published: 12/8/2021
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Inventor(s): Steven Zheng
Keywords(s): Drug Discovery/Screening
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics
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Methods to Produce Hepatitis C Virus E2 Protein
Invention Summary:Rutgers scientists have developed methods to produce and purify the ectodomain of HCV E2, a critical structural protein of the virus that has potential to serve as a vaccine candidate to prevent HCV infection. Efforts to study HCV, and to develop vaccines, have been impaired in part by the inability to produce sufficient quantities...
Published: 12/8/2021
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Inventor(s): Joseph Marcotrigiano, Jillian Whidby
Keywords(s): Drug Discovery/Screening, Peptides
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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