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Modified Simmons Catheter
Neurointerventions with improved success
Invention Summary:
The global neurovascular catheter market size was valued at USD 2.88 billion in 2020 and is expected to expand at a compound annual growth rate of 6.7% from 2021 to 2028. Neurointerventionalists, interventional radiologists, cardiologists, and vascular surgeons often can have...
Published: 8/25/2022
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Inventor(s): Amit Singla
Keywords(s): Neurological disorder & neuropathic pain
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Medical Devices
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MicroRNA Based Therapeutics for Parkinson’s Disease
Protection of the mouse brain by microRNA-7 against the toxicity of a-synuclein (A) Tyrosine hydroxylase (TH) stained coronal section of mouse brain injected in the right striatum with AAV-miR-7 or non-targeting (NT) vector following by a-synuclein preformed fibrils (PFF) or PBS. (B) Substantia nigra sections. (C) Nigral dopamine neuron count. (D) Striatal...
Published: 8/23/2022
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Inventor(s): M. Maral Mouradian, Eunsung Junn
Keywords(s): Neurological disorder & neuropathic pain
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Use of Retinoids in Congenital Erythropoietic Porphyria
Zebrafish model of CEP develops bone phenotype resembling human disease
Invention Summary:
Congenital erythropoietic porphyria (CEP) is a rare genetic disorder leading to accumulation of uro/coproporphyrin-I (uro-I) in tissues due to inhibition of the enzyme uroporphyrinogen-III synthase. Clinical manifestations of CEP include bone fragility,...
Published: 8/18/2022
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Inventor(s): Bishr Omary
Keywords(s): Small molecules
Category(s): Technology Classifications > Therapeutics, Technology Classifications > Healthcare & Life Sciences
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Novel ChABC formulation with machine learning-guided automation
Invention Summary:
Spinal cord injury (SCI) leads to the formation of scar tissue. The scarring leads to the toughening of the extracellular matrix, or the cellular environment. One of the major concerns of SCI is the prevention of neuronal connection recovery, which can lead to paralysis or reduced control of the nervous system. For...
Published: 8/18/2022
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Inventor(s): Adam Gormley, Matthew Tamasi, Shashank Kosuri, Michael Webb, Carlos Borca, Roshan Patel
Keywords(s): Biomaterials, Polymers & Composites, Proteins, Spinal Cord
Category(s): Technology Classifications > Biomaterials, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Polymers/Composites/Materials, Technology Classifications > Software & Algorithms, Technology Classifications > Therapeutics
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Nitrous Oxide Sedation for the Dental Team (Video and DVD)
Invention Summary:
Nitrous Oxide Sedation for the Dental Team DVD is an instructional video for dental practitioners such as dental hygienists, assistants, dentists and students. The DVD teaches and shows how to monitor Nitrous Oxide Sedation (NOS).
Video Content:
Dr. Vaishali Singhal created the NOS DVD in response to a lack of supplemental educational...
Published: 8/15/2022
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Inventor(s): Vaishali Singhal, Matthew Rosenthal
Keywords(s): Video
Category(s): Technology Classifications > Software & Copyright, Technology Classifications > Dental, Technology Classifications > Education, Technology Classifications > Healthcare & Life Sciences
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SAHMI: Microbiome-based screening method for cancer and other diseases
Screening methodology and principle data identifying differences in
microbiome diversity from disease state in pancreatic cancer
Invention Summary:
The microbiome plays an essential role in the prognosis and progression of disease and health, as seen in cancers like pancreatic cancer. Pancreatic cancer is rising in majority of cancer...
Published: 7/28/2022
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Inventor(s): Subhajyoti De, Bassel Ghaddar
Keywords(s): Anti-cancer, Bioinformatics, Biomarkers, Cancer biomarkers
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics, Technology Classifications > Cancer
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Novel Maturation‐defective Attenuated Chlamydia Vaccine
Invention Summary:
Millions of American men and women are infected with Chlamydia each year. Without proper treatment, a substantial proportion of chlamydia-infected women may develop infertility and other health problems. To date, no Chlamydia vaccine is available.
Chlamydia is an obligate intracellular bacterium with a unique...
Published: 7/28/2022
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Inventor(s): Huizhou Fan
Keywords(s):
Category(s): Technology Classifications > Vaccine, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Infectious Disease
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Novel gene drive based on eliciting piRNA biogenesis in insect pests
Transgenic Anopheles gambiae larvae expressing fluorescent marker gene
Invention Summary:
Malaria is one of the most impactful diseases in tropical and subtropical regions and is transmitted through human contact with infectious mosquitoes. Crop pests create a large economic and social impact through direct damage to plants and spread...
Published: 7/28/2022
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Inventor(s): Cory Henderson, Christina Bergey
Keywords(s):
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Pest Control, Technology Classifications > Ag Biotech
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Continuous Process for API Formulation and Manufacturing
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A comparison of dissolution profiles for impregnated ibuprofen (IBU) tablets and direct compression IBU tablets
Invention Summary:
A major challenge in pharmaceutical product development is the formation of homogenous blends containing small amount of active pharmaceutical ingredients (APIs). Poor...
Published: 7/28/2022
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Inventor(s): Fernando Muzzio, Benjamin Glasser, Thamer Omar
Keywords(s): Chemical and petrochemical industry, Manufacturing
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences
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High Throughput Library Preparation of Long Genomic DNA Targets
Overall workflow for preparing the LASSO library.
Invention Summary:
Advances in DNA sequencing have led to an exponential increase in the quantity of sequence data, whereas limited achievable maximum gene length (<200 bp) can produce highly biased libraries with constraints on sequence homology....
Published: 7/28/2022
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Inventor(s): Biju Parekkadan, Lorenzo Tosi
Keywords(s):
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Research Tools
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