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Novel ChABC formulation with machine learning-guided automation
Invention Summary:
Spinal cord injury (SCI) leads to the formation of scar tissue. The scarring leads to the toughening of the extracellular matrix, or the cellular environment. One of the major concerns of SCI is the prevention of neuronal connection recovery, which can lead to paralysis or reduced control of the nervous system. For...
Published: 8/18/2022
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Inventor(s): Adam Gormley, Matthew Tamasi, Shashank Kosuri, Michael Webb, Carlos Borca, Roshan Patel
Keywords(s): Biomaterials, Polymers & Composites, Proteins, Spinal Cord
Category(s): Technology Classifications > Biomaterials, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Polymers/Composites/Materials, Technology Classifications > Software & Algorithms, Technology Classifications > Therapeutics
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Cellularized Nerve Regeneration Graft to Remediate Peripheral Nerve Injury
Invention Summary:
Peripheral Nerve Injuries (PNI) arising from physical trauma, cancers, or other nervous system pathologies are associated with higher costs and socioeconomic impact globally. Currently available technologies to remediate nerve injury are often unsuccessful in restoring nerve functions to its original capacity and...
Published: 12/8/2021
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Inventor(s): Sanjeeva Murthy, Zhiping Pang, Jeremy Perrelle, Jasmine Gamboa, Andrew Boreland
Keywords(s):
Category(s): Technology Classifications > Biomaterials
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PEG Nanocarriers, Nanogels
and Synthesis Methods
Invention Summary:
A novel platform of PEG-only nanocarriers and nanogels has been developed by Rutgers scientists. The nanocarriers can be used from 100Da-100- kDa and are capable of forming stable nanogels and nanogel aggregates in a variety of sizes from 20-30nm up to >1000nm. The carriers and gels have improved solubility over existing technologies...
Published: 12/8/2021
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Inventor(s): Patrick Sinko, Manjeet Deshmukh, Hilliard Kutscher, Stanley Stein, Simi Gunaseelan, Anupa Menjoge
Keywords(s): Biomaterials, Drug Delivery
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Biomaterials, Technology Classifications > Therapeutics
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Single-Step Multipurpose Surface Functionalization
Invention Summary:Surface functionalization offers a wide array of material properties, including wettability, chemical stability, biocompatibility, catalytic activity, sensing, antifouling, anti-microbial, and cell-affinity. Despite the great interest in controlling these properties, a surface functionalization technology that is simple, robust, and...
Published: 12/8/2021
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Inventor(s): Enver Izgu, Zhaojun Jia
Keywords(s):
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Biomaterials, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Polymers/Composites/Materials
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Film Forming Foam (FFF) for Burn Wounds/Burnflex
Invention Summary:
Many of the available burn dressings on the market use latex, PVC or polyurethane as means of barrier-like components to protect the patient from outside elements. The current use of these components presents a problem of waste and contamination. Other available options in the market are hydrogel-based dressings that may...
Published: 12/8/2021
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Inventor(s): Maricely Ramírez-Hernández, Tewodros Asefa, Jeffrey Boyd, Javiera Norambuena-Morales
Keywords(s): Antibacterial, Drug Delivery, Nanoparticles, Nanotechnology, Wound healing
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Nanotechnology, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Biomaterials, Technology Classifications > Consumer & Household Goods
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Biodegradable Scaffold for Advanced Stem Cell Therapy
Schematic diagram representing the self assembly of Laminin (ECM) and the MnO2 sheet
Invention Summary:
While regenerative stem cell therapy has been a promising approach for transplant medicine and surgery, there have been challenges due to low transplantation survival rate and poor selectivity in differentiation.
Researchers at Rutgers University...
Published: 7/28/2022
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Inventor(s): Ki-Bum Lee, Letao Yang
Keywords(s): Bioengineering scaffolds, Biomaterials, Tissue Engineering
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Biomaterials, Technology Classifications > Therapeutics
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Cell Culture Scale-Up via 3D Bioactive Microcapsule
Capsules are designed to protect cells from shear, non-fouling, and customized for ease-of-use and recovery of cells.
Invention Summary:
Industrial cell culture scale-up is a critical unit operation in biopharmaceutical processes. Culturing adherent cells is particularly challenging, since they can’t simply be cultured in suspension but instead...
Published: 12/8/2021
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Inventor(s): Biju Parekkadan, Ayesha Aijaz
Keywords(s):
Category(s): Technology Classifications > Biomaterials, Technology Classifications > Research Tools, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Cell Therapy
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Biomimetic, Bioactive Dental Implants
Left: 3D printed mold; Center: prototype bioactive implant; Right: prototype lateral incisor implant restored with acrylic temporary crown (after implantation).Invention Summary: While titanium dental implants are the current state of the art for tooth replacement, they involve an invasive surgical procedure and significant risks. Aside from intraoperative...
Published: 12/8/2021
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Inventor(s): Amir Fakhrzadeh
Keywords(s): Bioengineering scaffolds, Biomaterials, Implants, Polymers & Composites
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Biomaterials, Technology Classifications > Medical Devices, Technology Classifications > Dental, Technology Classifications > Polymers/Composites/Materials
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Improved Nerve Conduits for Treatment of Peripheral Nerve Injuries
Scanning electron microscope image of conduits
Invention Summary:
Nerve conduits are used for treatment of peripheral nerve injuries. However, the current conduits are associated with poor healing resulting from swelling and reduction of luminal volume, suture pull-out, collapse, kinking, compression, and lack of mechanical strength to withstand...
Published: 12/8/2021
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Inventor(s): Joachim Kohn
Keywords(s): Biomaterials, Neurological disorder & neuropathic pain, Polymers & Composites, Wound healing
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Biomaterials
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Nanotechnology-based Method for Treatment of Primary Ovarian Cancer and Prevention of Metastases
Two-in-one: Combined nanocarrier based targeted chemo and gene therapy1. Cellular penetration of naked siRNA (green) and siRNA delivered by nanocarrier (red), 2. Treatment of mice bearing metastatic ovarian cancer. a. Mice bearing xenografts of human metastatic cancer and histology of tumor tissue (before treatment), b. Mice bearing xenografts of human...
Published: 12/8/2021
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Inventor(s): Tamara Minko, Olga Garbuzenko, Oleh Taratula, Lorna RodrigueZ-Rust
Keywords(s): Anti-cancer, Nanoparticles, Nanotechnology
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Biomaterials
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