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MicroRNA Based Therapeutics for Parkinson’s Disease
Protection of the mouse brain by microRNA-7 against the toxicity of a-synuclein (A) Tyrosine hydroxylase (TH) stained coronal section of mouse brain injected in the right striatum with AAV-miR-7 or non-targeting (NT) vector following by a-synuclein preformed fibrils (PFF) or PBS. (B) Substantia nigra sections. (C) Nigral dopamine neuron count. (D) Striatal...
Published: 8/23/2022
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Inventor(s): M. Maral Mouradian, Eunsung Junn
Keywords(s): Neurological disorder & neuropathic pain
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Use of Retinoids in Congenital Erythropoietic Porphyria
Zebrafish model of CEP develops bone phenotype resembling human disease
Invention Summary:
Congenital erythropoietic porphyria (CEP) is a rare genetic disorder leading to accumulation of uro/coproporphyrin-I (uro-I) in tissues due to inhibition of the enzyme uroporphyrinogen-III synthase. Clinical manifestations of CEP include bone fragility,...
Published: 8/18/2022
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Inventor(s): Bishr Omary
Keywords(s): Small molecules
Category(s): Technology Classifications > Therapeutics, Technology Classifications > Healthcare & Life Sciences
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Novel ChABC formulation with machine learning-guided automation
Invention Summary:
Spinal cord injury (SCI) leads to the formation of scar tissue. The scarring leads to the toughening of the extracellular matrix, or the cellular environment. One of the major concerns of SCI is the prevention of neuronal connection recovery, which can lead to paralysis or reduced control of the nervous system. For...
Published: 8/18/2022
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Inventor(s): Adam Gormley, Matthew Tamasi, Shashank Kosuri, Michael Webb, Carlos Borca, Roshan Patel
Keywords(s): Biomaterials, Polymers & Composites, Proteins, Spinal Cord
Category(s): Technology Classifications > Biomaterials, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Polymers/Composites/Materials, Technology Classifications > Software & Algorithms, Technology Classifications > Therapeutics
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Novel Cationic Amphiphiles Control Biofilm Formation for Bacterial Vaginosis
Cationic amphiphiles greatly inhibits the biofilm formation of the pathogenic bacteria in BV.Cationic Amphiphile Concentration (μM)Invention Summary:Bacterial vaginosis (BV) is a common polymicrobial infection in women of reproductive age, affecting 10-30% of women in developed nations. BV can lead to serious complications such as abortion, premature...
Published: 12/8/2021
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Inventor(s): Kathryn Uhrich, Allison Faig
Keywords(s): Antibacterial, Biofilm, Biomaterials, Drug Delivery, Personal Care, Cosmeceuticals, Polymers & Composites
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Biodegradable and Versatile Copolymers to Promote Wound Healing
Invention Summary:Rutgers scientists have developed a copolymer formulation to stably release salicylic acid (SA). It holds the promise for promoting topical and surgical wound healing, as SA is known to reduce local pain and inflammation as well as potentially prevent fibrous adhesion formation by reducing scar tissue. The release is stable over a...
Published: 12/8/2021
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Inventor(s): Kathryn Uhrich, Sabrina Snyder
Keywords(s): Biomaterials, Drug Delivery, Neurological disorder & neuropathic pain, Wound healing
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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PEG Nanocarriers, Nanogels
and Synthesis Methods
Invention Summary:
A novel platform of PEG-only nanocarriers and nanogels has been developed by Rutgers scientists. The nanocarriers can be used from 100Da-100- kDa and are capable of forming stable nanogels and nanogel aggregates in a variety of sizes from 20-30nm up to >1000nm. The carriers and gels have improved solubility over existing technologies...
Published: 12/8/2021
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Inventor(s): Patrick Sinko, Manjeet Deshmukh, Hilliard Kutscher, Stanley Stein, Simi Gunaseelan, Anupa Menjoge
Keywords(s): Biomaterials, Drug Delivery
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Biomaterials, Technology Classifications > Therapeutics
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“Off-the-shelf” CAR-NK cells for SARS-CoV-2 targeting in COVID-19 treatment
S309-CAR cells show higher lysis of cells transfected with the RBD of the SARS-CoV-2 spike protein compared to control.
Invention Summary:
COVID-19 remains a pandemic and a critical medical concern across the world. Patients with severe symptoms who are admitted into the ER have grim prognosis and are sometimes faced with expensive and limited...
Published: 12/8/2021
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Inventor(s): Dongfang Liu, Minh Ma, Saiaditya Badeti
Keywords(s): Antiviral, Bioengineering scaffolds
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > COVID-19
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A Chemogenetic Therapy for Neuropathic Pain
Invention Summary:
Neuropathic pain (NP) typically arises as a consequence of a lesion or disease affecting peripheral nerve fibers. Prominent features in the pathophysiology of neuropathic pain include increased, ectopic neuronal activity in pain pathways. In general, NP is frequently refractory to conventional analgesics and currently there are...
Published: 12/8/2021
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Inventor(s): Gary Aston-Jones
Keywords(s): Neurological disorder & neuropathic pain
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Gene Therapy
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Cationic Amphiphile for Antimicrobial Applications
The structure of CAms 5a, 5b, 5c, 8a, 8b, and 8c
Invention Summary:
The development of antibiotic-resistant bacteria is a prevalent concern that has prompted the development of new antimicrobial agents. Naturally-occurring antimicrobial peptides (AMPs) offer advantages over conventional antibiotics due to a reduced development of resistance...
Published: 12/8/2021
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Inventor(s): Kathryn Uhrich, Yingyue Zhang, Allison Faig, Michael (mikhail) Chikindas
Keywords(s): Antibacterial, Biomaterials, Peptides
Category(s): Technology Classifications > Therapeutics, Technology Classifications > Healthcare & Life Sciences
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A Method to Predict the Response of Individual Patient to Cocktails of Radiopharmaceuticals, Chemotherapeutics or Other Agents
Representative pictures showing wide variation in cellular uptake of radiopharmaceuticals.
Invention Summary:
A number of therapeutic cocktails have been developed to treat various diseases including metastatic cancers. However, patients vary widely in their beneficial responses to such therapies. It has been found that the uptake of targeted therapeutic...
Published: 12/8/2021
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Inventor(s): Roger Howell, Behrooz Vaziri, Han Wu, Atam Dhawan
Keywords(s): Antibodies, Anti-cancer
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Cancer, Technology Classifications > Software & Algorithms, Technology Classifications > Software & Copyright
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