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High Throughput Library Preparation of Long Genomic DNA Targets
Overall workflow for preparing the LASSO library.
Invention Summary:
Advances in DNA sequencing have led to an exponential increase in the quantity of sequence data, whereas limited achievable maximum gene length (<200 bp) can produce highly biased libraries with constraints on sequence homology....
Published: 7/28/2022
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Inventor(s): Biju Parekkadan, Lorenzo Tosi
Keywords(s):
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Research Tools
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Novel System for High-Yield Production of Proteins and Protein Domains
Invention Summary:The synthesis of recombinant proteins using prokaryotic expression systems has been instrumental in producing valuable reagents for biomedical research and commercial products. However, the majority of in vivo expression systems have inherent limitations in most applications – including low yields, poor quality of the expressed...
Published: 12/8/2021
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Inventor(s): Gaetano Montelione, Stephen Anderson, Yuanpeng Huang, Thomas Acton
Keywords(s): Drug Discovery/Screening, Manufacturing, Peptides
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Research Tools
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PulseLab: An Integrated and Expandable Toolbox for Pulse Wave Velocity-base Blood Pressure Estimation
Invention Summary:
Cuff-less blood pressure (BP) estimation methods have been long pursued as substitutions for the conventional BP measurement methods to facilitate continuous and automatic monitoring of BP. The PWV (pulse wave velocity)-BP models, describing the relationship between the PWV and the BP, have been derived and used in recent...
Published: 8/23/2022
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Inventor(s): Laleh Najafizadeh, Weinan Wang
Keywords(s): Cardiovascular
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Research Tools, Technology Classifications > Software & Algorithms, Technology Classifications > Software & Copyright
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Method for Generating Memory T-cells In Vitro and Their Use in Immunotherapy
Invention Summary:
Dendritic cell-based immunotherapies have been tested for the treatment of cancer patients with limited success. The limited success is probably due to the ineffective activation of specific T-cells by injected dendritic cells. In vitro generation of memory T-cells that can respond to cancer cells could circumvent ineffective...
Published: 12/8/2021
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Inventor(s): Shigeko Yamashiro, Fumio Matsumura, Aya Matsumura
Keywords(s): Anti-cancer, Immunoassay
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Research Tools, Technology Classifications > Therapeutics
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Rapid Cell Assembly for 3D Culture
A. Schematic diagram showing the self-assembly of a spheroid.
B. Schematic showing transplantation of spheroids for the repair/regeneration of spinal cord
Invention Summary:
3D cell culture including organoid and spheroid cultures is at the center stage of biomedical research. It is widely applied in organ development research, disease modeling,...
Published: 12/8/2021
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Inventor(s): Ki-Bum Lee
Keywords(s): Bioengineering scaffolds, Tissue Engineering
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Research Tools
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dCas9 Protein Allele Sequestration for Improved CRISPR Gene Editing
Invention Summary:
CRISPR technology is widely used in research to edit genes
in animals and cell lines and is moving towards therapeutic use in the clinic. Inherent to almost all methods employed in gene editing is the lack of control in target gene usage. A method to direct cleavage of only a single target within a cell would be beneficial to research...
Published: 12/8/2021
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Inventor(s): Peter Romanienko, Ghassan Yehia
Keywords(s): Gene editing
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Gene Therapy, Technology Classifications > Research Tools
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Fluorescent Probe for Bacterial Cell Imaging and Screening of New Antibacterial Drugs
Visualization of the impact of FtsZ-targeting drug treatment in both Gram-positive and Gram-negative bacterial strains using BOFP. Bacteria were labeled with BOFP for 5 minutes just prior to visualization. Differential interference contrast (DIC) shows unstained bacteria and fluorescence shows BOFP-labeled bacteria.Invention Summary:At least 2.8 million...
Published: 12/8/2021
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Inventor(s): Daniel Pilch, Edgar Ferrer-Gonzalez, Edmond LaVoie
Keywords(s): Drug Discovery/Screening
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Infectious Disease, Technology Classifications > Research Tools
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Novel Array Insert for One-Step 3D Cultures and Histological Processing
Schematic diagram of the technology. Organoid cultures can be grown in a basket array the size of a 96-well plate. The array can be shrunk down to fit into a histology cassette without need to transfer the culture.Invention Summary:Organoids are multicellular 3D structures that faithfully mimic their in vivo organ counterparts and are valuable tools...
Published: 12/8/2021
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Inventor(s): Hatem Sabaawy, Howon Lee, Chen Yang, Daehoon Han
Keywords(s): Drug Discovery/Screening
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Research Tools, Technology Classifications > Healthcare & Life Sciences
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Multilayer Stackable Tissue Culture Platform for 3D Co-Culture
Invention Summary:
In a native tissue inside an animal, different types of cells co-exist and communicate with one another through the surrounding microenvironment using chemical and mechanical signaling. The lack of technology to recreate such a microenvironment in in vitro models results in either under or over prediction of results using conventional...
Published: 7/28/2022
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Inventor(s): Martin Yarmush, Anil Shrirao, Rene Schloss, Ileana Marrero-Berrios
Keywords(s):
Category(s): Technology Classifications > Research Tools, Technology Classifications > Physical Sciences & Engineering
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Low Profile Transfer Mechanism for Controlled Environments
Invention Summary:Various scientific and manufacturing processes are performed in special controlled environments (e.g., ultra-high vacuum, high radiation, air-stable, etc.) that require special chambers that maintain the desired environment. A device such as a superconducting magnet or cryostat is housed within the chamber that requires objects to...
Published: 12/8/2021
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Inventor(s): Guohong Li, Eva Andrei
Keywords(s): Imaging, Machines & Instruments, Spectroscopy
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Research Tools
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